Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
نویسندگان
چکیده
منابع مشابه
P136: Role of Muscarinic Receptors in Schizophrenia
Schizophrenia is a severe psychiatric illness with a lifetime prevalence of ˜1% that imposes a huge toll on patients, their families and public health services worldwide. Delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior and negative symptoms constitute the core symptoms of schizophrenia. Although the neurotransmitter dopamine plays a prominent role in t...
متن کاملp136: role of muscarinic receptors in schizophrenia
schizophrenia is a severe psychiatric illness with a lifetime prevalence of ˜1% that imposes a huge toll on patients, their families and public health services worldwide. delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior and negative symptoms constitute the core symptoms of schizophrenia. although the neurotransmitter dopamine plays a prominent role in t...
متن کاملDecreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation.
BACKGROUND Acetylcholine is important to hippocampal function, including the processes of learning and memory. Patients with schizophrenia show impaired learning and memory and hippocampal dysfunction. Thus, acetylcholinergic systems may be primarily or secondarily disrupted in the hippocampal formation of schizophrenic patients. The present study tested the hypothesis that [(3)H]pirenzepine-la...
متن کاملWidespread decreases in cortical muscarinic receptors in a subset of people with schizophrenia.
These studies were undertaken to investigate the selectivity of cortical muscarinic receptor radioligand binding in muscarinic M(1) and M(4) receptor knockout mice and to determine whether a marked decrease in [(3)H]pirenzepine binding in Brodmann's area (BA) 9 from a subset of people with schizophrenia was predictive of decreased muscarinic receptors in other central nervous system (CNS) regio...
متن کاملDecreased regional cortical gray matter volume in schizophrenia.
OBJECTIVE The authors hypothesized that cortical gray matter volume reduction in schizophrenia is greatest in the heteromodal association cortex. This area comprises a highly integrated, reciprocally interconnected system that coordinates higher order cortical functions. METHOD Total brain and regional gray matter volumes were calculated in 46 schizophrenic patients and 60 age and sex-matched...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2008
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2008.28